pentobarbital will decrease the extent or influence of celecoxib by affecting hepatic enzyme CYP2C9/10 metabolism. small/importance unidentified. pentobarbital will lower the level or outcome of suvorexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/observe. robust CYP3A4 inducers may perhaps lessen suvorexant efficacy; i